Scientific journal
Название журнала на английском
ISSN 2500-0802
ПИ №ФС77-61154

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RESEARCH GHEPATOPROTECTIVE AND CHOLAGOGIC ACTIVITY PHYTOSUBSTANCES OFWILD FENNEL

Mashirova S.Y. 1
1 Pyatigorsk branch SBEI HPE “Volgograd State Medical University” Ministry of Health of Russia
Researchin ghepatoprotective and cholagogic activity ofthe phytosubstances received from seeds ofwild fennel, dry extract, fatty oil and essential oil. The assessment of hepatoprotective activity of phytosubstances is executed on a model of acute СС14-hepatosis in their health-care oraladministration. The research of choleresis functions of a heparcarried out after 10-days oforal administration ofthe substances to the healthy animals.Application of dry extract at a dose of 200 mg/kg againstacute СС14-hepatosis have reduced theintensity ofcytolytic processesand a giperbilirubinemiya (decrease in concentration of fraction of free bilirubin), without considerable influence on intensity of cholestasis. Oral administration of fatty oil at dosage of 100 mg/kg was accompanied decrease intensity of hyperenzymemia, bilirubinemia(reduced concentrations of total and direct bilirubin), a decrease in blood cholesterol and triglycerides in hepar. Choleretic activity of dry extract and fatty oil was studied in similar doses. The essential oil was investigated in a series of doses - 20 mg / kg, 50 mg / kg, 100 mg / kg, 200 mg / kg, 400 mg / kg, 800 mg / kg. Oral administration of dry extract to healthy animals did not accompany by an increase of the volume of bile secreted. In the group of animals treated with a fattyoil, there was a significant increase in the number of bile flow by 27%. Oral administration of increasing doses of essential oil led to a significant increase of bile secretion at doses of 200 mg / kg and 400 mg / kg. Thus, the dry extract and fatty oil in СС14-hepatosis have a protective effect on the hepar, characterized by target different stages of pathogenesis - dry extract more effectively inhibits lipid peroxidation, reducing damage to the membranes of hepatocytes and preventing them from cytolysis, fatty oil reduces the intensity of cytolytic processes due to the repair of damaged pieces of the membrane of hepatocytes due to its fatty acid composition. And more effectively eliminates cholestasis and exhibits choleretic activity.