Scientific journal
Название журнала на английском
ISSN 2500-0802
ПИ №ФС77-61154

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COLLIGATIVE PROPERTIES OF SOLUTIONS OF HUMAN LEUKOCYTIC INTERFERON ALPHA

Minyaeva O.A. 1 Botova D.I. 1 Nelyubina E.S. 1
1 South Ural State Medical University
Colligative properties of aqueous solutions of human leukocyte interferon alpha studied. The linear dependence of freezing point depression of the concentration of interferon alpha in the solution set. This is analogous to previously obtained curves for albumin, normal and anti-mite immunoglobulins. This allows recommending osmometry method as a fast and precise method for determining the concentration of individual proteins in aqueous solutions, including pharmaceuticals. The linear dependence of the effective osmotic concentration and osmotic pressure of the protein content of the solution is installed in the concentration range of 0 - 10% for the human leukocyte interferon alpha. A zero value of the constant b, which takes into account the flexibility and shape of macromolecules in the equation Haller, found. The existence of only spherical globular conformation of protein macromolecules of human leukocyte interferon alpha in the investigated range of concentrations proved.