Scientific journal
Название журнала на английском
ISSN 2500-0802
ПИ №ФС77-61154

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MODIFICATION OF α-HYDROXY-β-DIALKYLAMINOALKYLBENZOIC ACIDS IN SYNTHESIS OF NEW ANKSIOLITIK

Kamkina N.V. 1 Krasnikov S.V. 1
1 FGBOY VPO «Yaroslavl state technical university»
By means of reaction of O-acylation (benzoylation) α-hydroxy-β-dialkylaminoalkylbenzoic acids the 4-substituted benzoic of acids are received and characterized by a series of hlorangidrid α-phenylkarbonyloxy-βdialkylaminoalkylbenzoic acids with an exit of 70-75% which can possess anksiolitichesky activity. Influence of conditions of O-acylation (benzoylation) on an exit of the specified acids is investigated. O-Acylation (benzoylation) was carried out at a ratio p- R-С6Н4СОСl /substrata, equal 3/1, in mix of the solvents acetone / N, N-dimetilformamid at the ratio equal 1/1. It is studied influences of temperature, the specified reaction proceeds only at boiling of reactionary mix, and full conversion initial α-hydroxy-β-dialkylaminoalkylbenzoic acids was observed at time of reaction of 25 h. Individual techniques of allocation new α-phenylkarbonyloxy-β-dialkylaminoalkylbenzoic acids are developed, and their structure is proved by means of spectroscopy IK and NMR1H.