Scientific journal
Название журнала на английском
ISSN 2500-0802
ПИ №ФС77-61154

SYNTHESIS OF NEW N-ALKYLATED DERIVATIVES OF 1-ETHINYL-1-AMINOCYCLOHEXANE

Dzhiembaev B.Z. 1 Baramysova G.T. 2 Ahataev N.A.,1Nurgozhaeva A.M. 2 Appazov N.O. 1 Zhoraeva G.Z. 2 1
1 Kazakh State Women’s Pedagogical University
2 Kyzylorda State University named after Korkyt Ata
It is performed the synthesis of 1-ethinyl-1-aminophenalcyclohexane and 1-ethinyl-1-aminopropynyl-cyclohexane reacting 1-ethinyl-1-aminocyclohexane bromide phenacyl and romide propargyl. Subsequently, based on N-substituted amines obtained their acylated, phosphonylated, phosphorylated derivatives and hydrazones. Performing chemical transformation 1-ethynyl-1-amino-cyclohexane molecules confirmed the high reactivity of the alkylation acetylenic amine at bromide phenacyl and bromide propargyl. Extending the experimental data on chemical modifications on the basis of 1-ethinyl-1-aminocyclohexane can assume that the new functionalized nitrogen and phosphorus derivatives of acetylenic amine are the great practical interest as biologically active compounds. The resulting products were identified by IR and NMR spectroscopy. Control over the progress of the reaction was monitored by TLC on alumine plates in different solvent systems, developing agent is iodine.