Scientific journal
Название журнала на английском
ISSN 2500-0802
ПИ №ФС77-61154

GENOME OF SALMONELLAS

Chugunova E.O. 1 Tatarnikova N.A. 1
1 Permskaya state agricultural academy
The genome of salmonellas consists of one ring chromosome of 4.8 million couples in size of nucleotides and a number of plasmids from 3 to 100 thousand couples of nucleotides. Genetic variety of salmonellas depend on the spot island of pathogenicity (SPI). The island of pathogenicity-1 (SPI-1) represents a site of DNA of 40 thousand couples in size of the bases. SPI-2 has the size of 40 thousand couples. SPI-3 has the size of 36 thousand couples of the bases, participates in process of an intracellular survival and codes magnesium transport. SPI-4 represents 24 thousand couples and participates in adhesion to epithelial cells. SPI-5 has less than 8 thousand couples in size. It is necessary for inoculation to intestines epithelial cells. SPI - 6 codes work of T6SS. SPI-7 is the biggest island of pathogenicity today. It contains genes of biosynthesis of a Vi-capsular anti-gene. It is responsible for a virulence of a bacterium. SPI-8 is represents a fragment of DNA and it is part SPI-13. SPI-9 is represents a locus of 16 thousand couples in size and contains three genes coding T1SS. SPI-10 is consists of 33 thousand couples (in S. typhi) and includes some functionally untied genes. SPI-11 help to survive salmonellas inside macrophagocytes. SPI-12 is codes specific O-antigeny. SPI-13 consists of 25 thousand couples. SPI-14 is consist of 9 thousand couples. It is codes cytoplasmic proteins. SPI-15 is consist of 6.5 thousand couples. SPI-16 makes of 4.5 thousand couples. SPI-17 codes the island in 5 thousand couples. SPI-18 is consist of 2.3 thousand couples. It is responsible for an invasion of salmonellas in epithelial cells of intestines of person. Other islands of pathogenicity weren’t identified as SPI modules, but they code the genes responsible for a virulence of a bacterium.