Alekseev A.V. 1
Volkova L.R. 2
Zubareva G.M. 1
1 Tver State Medical Academy
2 ГБОУ ВПО Тверская государственная медицинская академия Минздрава России
There are numerous articles about the action of different preparations on biological systems. The substances used for the treatment of eye diseases are pilocarpine hydrochloride, betaxolol hydrochloride and epinephrine whose mechanism of action is aimed at drop of intraocular pressure; however there are no data regarding their action in very-low-doses. At that in press there is information which explains the mechanism of action of medicinal preparations by means of their effect on the water component of biological ﬂuids. The aim of the article is to reveal the peculiarities of the effect of hypotensive eye remedies with different chemical structure on the water component of test solutions. Deionized redistilled water, solutions of pilocarpine, betaxolol and epinephrine in the initial concentration of 1% were used as test ﬂuids. The samples under study were prepared in fused silica ﬂasks immediately prior to spectrum taking by means of tenfold serial dilution of the initial solutions from 101 to 1016 times. After that infrared spectrometry with transmittance spectra registration in the range of 3500-963 cm-1 was performed. It was estimated that the substances under study caused speciﬁc changes in the water component depending on their nature and amount.