Scientific journal
Название журнала на английском
ISSN 2500-0802
ПИ №ФС77-61154

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TRANSFORMATION OF CELLS UNDER THE INFLUENCE OF BOVINE LEUKEMIA VIRUS IS A REAL RISK OF DEVELOPING THE ONCOLOGICAL DISEASES IN HUMANS

Khazipov N.Z. 1 Vafin R.R. 1, 2 Shaeva A.Y. 1 Zaynullin L.I. 2
1 «Kazan state academy of veterinary medicine»
2 «Kazan (Volga region) federal university»
Bovine leukemia virus (BLV) is a RNA-containing retrovirus, with a human T-lymphotropic virus (HTLV-1 and HTLV-2) belongs to the family Retroviridae, subfamily Oncornaviridae. BLV is the causative agent of widespread slow infection of bovine leukemia. This exogenous virus in natural conditions affects only cattle. The virus can replicate in cell cultures of cattle, sheep, human, monkeys, dogs, goats and horses. During the pathogenesis causes destabilization of the cell genomes, that leads to the formation of syncytia, activation of tax gene that causes malignant transformation of a cell genome. These effects are not unique to cells in cattle, but also occur when BLV interaction with cells of other species of animals, including humans, i.e. BLV in contact with human cells (in cell culture) destabilizes the genome with various chromosome changes. This in turn is causing the development of a tumor, i.e. transformation of cells by BLV represents a real risk of developing the oncological diseases in humans.